If the decision is made to use Depakote, you should use effective birth control contraception. Tell your healthcare provider right away if you become pregnant while taking Depakote. You and your healthcare provider should decide if you will continue to take Depakote while you are pregnant. If you become pregnant while taking Depakote, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry.
You can enroll in this registry by calling The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy. Inflammation of your pancreas that can cause death. Call your healthcare provider right away if you have any of these symptoms: Like other antiepileptic drugs, Depakote may cause suicidal thoughts or actions in a very small number of people, about 1 in Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you: How can I watch for early symptoms of suicidal thoughts and actions?
Pay attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you are worried about symptoms. Do not take Depakote if you: Ask your healthcare provider about the best way to feed your baby. Taking Depakote with certain other medicines, even for a short period of time, can cause side effects or affect how well they work.
Do not start or stop other medicines without talking to your healthcare provider. Depakote can cause other serious side effects, including: High ammonia levels in your blood: Low body temperature hypothermia: Drowsiness or sleepiness in the elderly.
You should not use Depakote if you have liver disease, a urea cycle disorder, or a genetic disorder such as Alpers' disease or Alpers-Huttenlocher syndrome especially in a child younger than 2 years old. Depakote can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by a genetic mitochondrial MYE-toe-KON-dree-al disorder.
Call your doctor at once if the person taking this medicine has early signs of liver or pancreas problems, such as: Before taking this medicine You should not use Depakote if you are allergic to divalproex sodium, or if you have: Depakote can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by a genetic mitochondrial disorder. To make sure this medicine is safe for you, tell your doctor if you have: Some young people have thoughts about suicide when first taking Depakote.
Your doctor will need to check your progress at regular visits while you are using this medicine. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not use Depakote to prevent migraine headaches if you are pregnant. This medicine can harm an unborn baby or cause birth defects, and may affect cognitive ability reasoning, intelligence, problem-solving later in the child's life. However, having a seizure during pregnancy could harm both the mother and the baby.
Use effective birth control while using Depakote, and tell your doctor right away if you become pregnant. Tell your doctor if you start or stop using hormonal contraception that contains estrogen birth control pills, injections, implants, skin patches, and vaginal rings.
Estrogen can interact with divalproex sodium and make it less effective in preventing seizures. Seizure control is very important during pregnancy. The benefit of preventing seizures may outweigh any risks posed by taking Depakote. There may be other seizure medications that can be more safely used during pregnancy. Follow your doctor's instructions about taking this medicine while you are pregnant. Divalproex sodium can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take Depakote? Take Depakote exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day. You may open the Depakote sprinkle capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier.
Swallow this mixture right away. Do not crush, chew, break, or open a delayed-release or extended-release tablet or capsule. While using Depakote, you may need frequent blood tests. Wear a medical alert tag or carry an ID card stating that you take Depakote.
Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication. If you need surgery, tell the surgeon ahead of time that you are using Depakote. Do not stop using Depakote suddenly, even if you feel fine.
Stopping suddenly may cause a serious, life-threatening type of seizure. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture and heat.
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