Adverse reactions for 3 of these patients included abdominal discomfort, fatigue, and dyspnea. In addition, based on the pharmacology of Maxalt, hypertension or myocardial ischemia could occur after overdosage. Clinical and electrocardiographic monitoring should be continued for at least 12 hours, even if clinical symptoms are not observed. The effects of hemo- or peritoneal dialysis on serum concentrations of rizatriptan are unknown.
Rizatriptan benzoate is described chemically as: N,N-dimethyl 1H-1,2,4-triazolylmethyl -1H-indoleethanamine monobenzoate and its structural formula is: Each compressed tablet contains the following inactive ingredients: Each lyophilized orally disintegrating tablet contains the following inactive ingredients: Pharmacokinetics Absorption Rizatriptan is completely absorbed following oral administration. The presence of a migraine headache did not appear to affect the absorption or pharmacokinetics of rizatriptan.
Food has no significant effect on the bioavailability of rizatriptan but delays the time to reach peak concentration by an hour. In clinical trials, Maxalt was administered without regard to food. No accumulation occurred on multiple dosing.
Distribution The mean volume of distribution is approximately liters in male subjects and liters in female subjects. The plasma half-life of rizatriptan in males and females averages hours.
Rizatriptan pharmacokinetics in healthy elderly non-migraineur volunteers age years were similar to those in younger non-migraineur volunteers age years. The pharmacokinetics of rizatriptan was determined in pediatric migraineurs 6 to 17 years of age.
Pharmacokinetic data revealed no significant differences between African American and Caucasian subjects.
Drug Interactions [See also Drug Interactions 7. Plasma concentrations of rizatriptan may be increased by drugs that are selective MAO-A inhibitors e. The interaction would be expected to be greater with irreversible MAO inhibitors. If you have a headache that is different from your usual migraine attacks, check with your doctor before using Maxalt. Diabetes patients - Maxalt may affect your blood sugar. Check blood sugar levels closely.
Ask your doctor before you change your diet or the dose of your diabetes medicine. Maxalt should not be used in children younger 18 years; safety and effectiveness in these children have not been confirmed. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Maxalt while you are pregnant.
It is not known if Maxalt is found in breast milk. If you have taken ergotamine , methysergide, dihydroergotamine , or any drug like them in the last 24 hours. This is not a list of all drugs or health problems that interact with Maxalt-MLT rizatriptan orally disintegrating tablets.
Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. You must check to make sure that it is safe for you to take Maxalt-MLT rizatriptan orally disintegrating tablets with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Tell all of your health care providers that you take Maxalt-MLT rizatriptan orally disintegrating tablets. This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for you to be alert until you see how Maxalt-MLT rizatriptan orally disintegrating tablets affects you. This medicine is not meant to prevent or lower the number of migraine headaches you get.
Talk with your doctor. Use care if you have risks for heart disease high blood pressure, high cholesterol , overweight , high blood sugar or diabetes, cigarette smoking , man older than 40 years of age, other family members with early heart disease, woman after change of life. Taking more of Maxalt-MLT rizatriptan orally disintegrating tablets a higher dose, more often than your doctor told you to take may cause your headaches to become worse. If you have phenylketonuria PKU , talk with your doctor.
Heart 0 Doses of Maxalt work differently in different people. You and your doctor can weigh the possible benefit of a higher dose of Maxalt with possible side-effect risks. Weighing benefits and risks is true for both dosage forms of Maxalt, the regular tablets or the tablets that dissolve in your mouth. By keeping a migraine journal of what doses you are taking when you experience a migraine, you can be prepared to discuss how well the drug works during your visits to your doctor.
Be sure to share your headache log with your doctor at your next appointment. Your doctor may prescribe either a 5-mg or mg dosage of Maxalt or Maxalt-MLT for your migraine attack.
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