Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic. Attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. Diazepam may be used to control convulsions. Acidosis and electrolyte losses should be corrected. Note that any depressant effects of Promethazine HCl are not reversed by naloxone.
Avoid analeptics which may cause convulsions. The treatment of choice for resulting hypotension is administration of intravenous fluids, accompanied by repositioning if indicated. In the event that vasopressors are considered for the management of severe hypotension which does not respond to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine should be considered.
Extrapyramidal reactions may be treated with anticholinergic antiparkinsonian agents, diphenhydramine, or barbiturates. Oxygen may also be administered. Limited experience with dialysis indicates that it is not helpful.
Allergy The average oral dose is 25 mg taken before retiring; however, Children tolerate this product well. Single 25 mg doses at bedtime or 6. After initiation of treatment in children or adults, dosage should be adjusted to the smallest amount adequate to relieve symptoms. The administration of Promethazine HCl in 25 mg doses will control minor transfusion reactions of an allergic nature.
Motion Sickness The average adult dose is 25 mg taken twice daily. The initial dose should be taken one-half to one hour before anticipated travel and be repeated 8 to 12 hours later, if necessary. On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. Children may be more sensitive to the side effects of this drug, especially slowed breathing see Warning section.
This drug can often cause excitement in young children instead of drowsiness. Special care should be taken when using this medication in children who have lost a lot of fluid dehydration , those who have a family history of sudden infant death syndrome SIDS , and those who are hard to wake up from sleep.
Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation , or trouble urinating. Children should be supervised to avoid potential harm in bike riding or in other hazardous activities. The concomitant use of alcohol or other CNS depressants, including narcotic analgesics, sedatives, hypnotics and tranquilizers, may have an additive effect and should be avoided or their dosage reduced.
Patients should be advised to report any involuntary muscle movements or unusual sensitivity to sunlight. Drug Interactions The sedative action of promethazine is additive to the sedative effects of other CNS depressants, including alcohol, narcotic analgesics, sedatives, hypnotics, tricyclic antidepressants and tranquilizers; therefore, these agents should be avoided or administered in reduced dosage to patients receiving promethazine.
Pregnancy Tests Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. Glucose Tolerance Test An increase in blood glucose has been reported in patients receiving promethazine.
Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine, nor are there other animal or human data concerning the carcinogenicity, mutagenicity or impairment of fertility with this drug. Promethazine was nonmutagenic in the Salmonella test system of Ames. Pregnancy Teratogenic Effects—Pregnancy Category C Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.
These doses are from approximately 2. Specific studies to test the action of the drug on parturition, lactation and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Although antihistamines, including promethazine, have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man. There are no adequate and well-controlled studies of promethazine in pregnant women.
Promethazine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at Overdose symptoms may include overactive reflexes, loss of coordination, severe drowsiness or weakness, fainting, dilated pupils, weak or shallow breathing, or seizure convulsions.
What should I avoid while taking promethazine? This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can increase certain side effects of promethazine.
Avoid exposure to sunlight or tanning beds. Precautions See also Warning section. Before taking this medication , tell your doctor or pharmacist if you are allergic to promethazine or to dextromethorphan ; or to any other phenothiazines such as prochlorperazine ; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details. Use in Pediatric Patients Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain is contraindicated for use in pediatric patients less than two years of age.
Caution should be exercised when administering Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain to pediatric patients 2 years of age and older because of the potential for fatal respiratory depression. Respiratory depression and apnea , sometimes associated with death, are strongly associated with promethazine products and are not directly related to individualized weight-based dosing, which might otherwise permit safe administration.
Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory depression, and sometimes death, in pediatric patients. Antiemetics are not recommended for treatment of uncomplicated vomiting in pediatric patients, and their use should be limited to prolonged vomiting of known etiology. The extrapyramidal symptoms which can occur secondary to Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain administration may be confused with the CNS signs of undiagnosed primary disease, e.
The use of Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain should be avoided in pediatric patients whose signs and symptoms may suggest Reye's syndrome or other hepatic diseases.
Hallucinations and convulsions have occurred with therapeutic doses and overdoses of Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain in pediatric patients. In pediatric patients who are acutely ill associated with dehydration , there is an increased susceptibility to dystonias with the use of promethazine HCl. Other Considerations Administration of promethazine HCl has been associated with reported cholestatic jaundice. Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine, nor are there other animal or human data concerning carginogenicity, mutagenicity, or impairment of fertility with this drug. Promethazine was nonmutagenic in the Salmonella test system of Ames. Pregnancy Teratogenic Effects-Pregnancy Category C Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.
These doses are from approximately 2.
The diagnostic evaluation of patients with this syndrome is complicated. You should not breast-feed while using this medicine. How often you take this medicine and the timing of your dose will depend on the condition being treated. Limited 6.25mg with dialysis indicates that it is not helpful, promethazine h 6.25mg. Active and prophylactic treatment of motion sickness. Avoid exposure to sunlight or tanning beds. What should I avoid while taking promethazine? Promethazine side effects Get emergency medical help if you have any signs of promethazine allergic reaction: Atropine-like signs and symptoms — dry mouth, fixed dilated pupils, flushing, promethazine h 6.25mg, as well as gastrointestinal symptoms, may occur. Patients should be advised to report any involuntary muscle movements. Promethazine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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