Tinidazole mission pharmacal - Specification
Tinidazole, like metronidazole, may produce transient leukopenia and neutropenia; however, no persistent hematological abnormalities attributable to tinidazole have been observed in clinical studies. Total and differential leukocyte counts are recommended if re-treatment is necessary. The appearance of abnormal neurologic signs demands the prompt discontinuation of tinidazole therapy.
Vaginal Candidiasis The use of tinidazole may result in Candida vaginitis. In a clinical study of women who received tinidazole for bacterial vaginosis, a vaginal fungal infection developed in 11 4.
Drug Resistance Prescribing Tindamax in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility Metronidazole, a chemically-related nitroimidazole, has been reported to be carcinogenic in mice and rats but not hamsters.
In several studies metronidazole showed evidence of pulmonary, hepatic, and lymphatic tumorigenesis in mice and mammary and hepatic tumors in female rats. Tinidazole carcinogenicity studies in rats, mice or hamsters have not been reported.
Tinidazole was mutagenic in the TA , S. Mutagenicity results were mixed positive and negative in the TA , , and strains. Tinidazole was also mutagenic in a tester strain of Klebsiella pneumonia.
Tinidazole was negative for mutagenicity in a mammalian cell culture system utilizing Chinese hamster lung V79 cells HGPRT test system and negative for genotoxicity in the Chinese hamster ovary CHO sister chromatid exchange assay.
Tinidazole was positive for in vivo genotoxicity in the mouse micronucleus assay. This effect is characteristic of agents in the 5-nitroimidazole class. Since tinidazole crosses the placental barrier and enters fetal circulation it should not be administered to pregnant patients in the first trimester.
Although there is some evidence of mutagenic potential and animal reproduction studies are not always predictive of human response, the use of tinidazole after the first trimester of pregnancy requires that the potential benefits of the drug be weighed against the possible risks to both the mother and the fetus. Nursing Mothers Tinidazole is excreted in breast milk in concentrations similar to those seen in serum.
Tinidazole can be detected in breast milk for up to 72 hours following administration. Interruption of breast-feeding is recommended during tinidazole therapy and for 3 days following the last dose. Pediatric Use Other than for use in the treatment of giardiasis and amebiasis in pediatric patients older than three years of age, safety and effectiveness of tinidazole in pediatric patients have not been established.
Geriatric Use Clinical studies of tinidazole did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Hepatic Impairment There are no data on tinidazole pharmacokinetics in patients with impaired hepatic function. Reduced elimination of metronidazole, a chemically-related nitroimidazole, has been reported in this population. Treatment Of Overdosage There is no specific antidote for the treatment of overdosage with tinidazole; therefore, treatment should be symptomatic and supportive.
Gastric lavage may be helpful. Prophylaxis against sexually transmitted diseases following sexual assault off-label use: Compliance with initial regimen and lack of reexposure to an untreated sex partner should be excluded prior to use CDC [Workowski ] Dosing: Geriatric Refer to adult dosing. Refer to adult dosing. Renal Impairment No dosage adjustment necessary. Crush four mg tablets in a mortar and reduce to a fine powder. Add 10 mL cherry syrup and mix to a uniform paste; mix while adding cherry syrup in incremental proportions to almost 30 mL; transfer to a calibrated bottle, rinse mortar with vehicle, and add quantity of vehicle sufficient to make 30 mL.
Stable for 7 days. Dietary Considerations The manufacturer recommends that ethanol be avoided during treatment and for 3 days after therapy is complete. Drug Interactions Alcohol Ethyl: A disulfiram-like reaction may occur. Avoid combination BCG Intravesical: Antibiotics may diminish the therapeutic effect of BCG Intravesical. Monitor therapy Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine.
Avoid combination Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.
Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine.
In a clinical study of women who received tinidazole for bacterial vaginosis, a vaginal fungal infection developed in 11 4. Avoid combination BCG Intravesical: Prophylaxis against sexually transmitted diseases following sexual assault off-label use: Pharmacal Label Uses Helicobacter pylori eradication Based on the American College of Gastroenterology Clinical Guideline for the Treatment of Helicobacter missions Infectiontinidazole is an effective and recommended component of a multiple-drug regimen for the treatment of this condition. Pediatric Use Other than for use in the treatment of giardiasis and amebiasis in pediatric patients older than three years of age, safety and effectiveness of tinidazole in pediatric patients have not been established. Amoxicillin 1 tinidazole twice daily plus a standard-dose proton pump inhibitor twice daily for 5 to 7 days; then follow with clarithromycin mg twice daily, tinidazole mission pharmacal, tinidazole mg twice daily, and a standard-dose proton pump inhibitor daily for 5 to 7 days. Lithium Metronidazole has been reported to elevate serum lithium levels. Cyclosporine, Tacrolimus There are several case reports suggesting that metronidazole has the potential to increase the levels of cyclosporine and tacrolimus. Reduced elimination of metronidazole, a chemically-related nitroimidazole, has been reported in this population. American College of Gastroenterology guidelines Chey ; Chey Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Values of zero may be observed. The dosage of oral anticoagulants may need to be adjusted during tinidazole co-administration and up to 8 days after discontinuation. Dysgeusia bitter taste, metallic taste: Antibiotics may diminish the therapeutic achat levitra sur internet of Typhoid Vaccine. Crush four mg tablets in a mortar and reduce to a fine powder.